Measure molecular chirality. Directly

Raman Optical Activity spectrometer

Raman scattering provides vibrational information about a sample and is widely used as a molecular fingerprint. It helps identify chemical structure, bonding, and composition. On its own, however, conventional Raman spectroscopy is generally not sensitive to molecular handedness.

ROASPECT is research-grade Raman Optical Activity spectrometer that measures molecular chirality directly in solution.

— In a single measurement, ROASPECT captures both the conventional Raman spectrum and its chiroptical ROA counterpart – chemical identity and molecular handedness, side by side. It links this vibrational fingerprint to absolute configuration and quantifies enantiomeric excess with sub-1 % precision in one minute – on samples down to 5 µL, with automated self-calibration. This is chirality you can trust – in research and in pharma.

Palacký University Olomouc

Department of Optics 25+ years of ROA research led by Dr. Josef Kapitán. Methodological and scientific backbone to measurement, interpretation, and application of Raman Optical Activity.

ZEBR s.r.o.

Precision mechanics and engineering 35+ years of precision-engineering expertise and patented opto-mechanical technology. Turns demanding ROA physics into a robust, reliable instrument.

Why
ROASPECT?

Ultrafast, stable, robust & reliable

Research & Production Solution

For research and industrial use

Modular Raman and ROA platform

Absolute configuration assignment

Fast enantiomeric excess analysis

Flexible motorized sample space

Core
Applications

Absolute Configuration

Assign 3D stereochemistry directly from spectra – comparison of measured ROA with first-principles simulation resolves ambiguous configurations.

Enantiomeric Excess Quantitative

EE analysis in Raman-active chiral solutions – sub-1 % precision in one minute, 0.05 % standard deviation in EE after extended measurement.

Molecular Structure & Conformation

ROA is exquisitely sensitive to conformation, deuteration, molecular folding, weak intramolecular interactions and much more – structural details beyond conventional Raman.

Pharmaceutical Analytics

Chirality-sensitive measurement close to the point of decision – for development, analytical verification, and workflow exploration.

Chirality defines drug success. ROASPECT provides the stereochemical evidence essential for efficacy, safety, and commercial value.

See the Data

Explore ROA spectra measured on ROASPECT - select a sample and find out

Sample handling:

From Micro-volumes to Batch Automation

Micro Volume Analysis

Standard measurement volumes <70 uL.
Specialized design for scarce samples, low concentrations and capillary flow systems (<5 uL).

Temperature Stability

Temperature range -10 – 95 °C with an unparalleled resolution of 0.1 °C.
Stabilized environment effectively prevents sample degradation.

Precise 3D Positioning

Motorized sample stage with 50 mm range along XYZ.
Horizontal precision of 1 µm, vertical 10 µm, including repeatable focus control.

Attachment Flexibility

Batch analysis with automated switching of up to 5 samples.
Rotational holders for suspended, crystalline, or custom solutions.

ROASPECT is built around measurement credibility, not oversimplified automation.

Spectrometer

532 nm excitation
back-scattering geometry.
SCP, ICP, DCPI, DCPII on one instrument – cross-validation that distinguishes true chiroptical signal from artefact.

Broad spectral range

80 – 4500 cm⁻¹ with ∼7cm⁻¹ resolution covers all at once: fingerprint, hydrogen stretching and phonon regions of samples.

Automated self-calibration

Insert and measure – no wavenumber calibration sample or manual intervention required.

Sample flexibility

<70 µL and <5 µL cuvettes
capillary arrays
temperature control -10 to +95 °C rotational sample holders, crystalline and custom samples.

Integrated control

Dedicated software
motorized 1 µm XYZ sample stage with automatic positioning and focus control.

Safety

Class 1 laser device with laser interlocks
safety sample compartment doors
Fully integrated UPS.

Scientific
foundation

RNDr. Josef Kapitán, Ph.D. and his team

bring more than 15 years of experience in Raman Optical Activity. Their work is rooted in the Department of Optics at Palacký University Olomouc, a respected institution with 450+ years of academic tradition and decades of expertise in advanced optical research positioning it as a major optical research center in Czech Republic.

This background gives ROASPECT a strong methodological foundation in ROA methodology, measurement, interpretation, and application.

Measure molecular chirality. Directly